Rest API Documentation - Project drugs

1. Get drug

Returns drug data with project related connections.

1.1. CURL sample 1

$ curl 'https://minerva-service.lcsb.uni.lu/minerva/api/projects/test_project/drugs:search?query=aspirin' -X GET \
    --cookie "MINERVA_AUTH_TOKEN=xxxxxxxx"

1.2. CURL sample 2

$ curl 'https://minerva-service.lcsb.uni.lu/minerva/api/projects/Some_id/drugs:search?target=ALIAS:320' -X GET \
    --cookie "MINERVA_AUTH_TOKEN=xxxxxxxx"

1.3. Path Parameters

Table 1. /minerva/api/projects/{projectId}/drugs:search
Parameter	Description
`projectId`	project identifier

1.4. Request Parameters

Parameter Description

Parameter	Description
`columns`	set of columns (all by default). Available options: name, references, description, synonyms, id, directEvidenceReferences, directEvidence, targets
`query`	name of chemical that we are searching for
`target`	target element that we are searching for in format TYPE:ID

columns

set of columns (all by default). Available options: name, references, description, synonyms, id, directEvidenceReferences, directEvidence, targets

query

name of chemical that we are searching for

target

target element that we are searching for in format TYPE:ID

1.5. Response Fields

Path Type Description

Path	Type	Description
`[].id`	`String`	identifier of the chemical
`[].name`	`String`	name
`[].description`	`String`	description
`[].synonyms`	`array<string>`	list of synonyms
`[].brandNames`	`array<string>`	list of brand names
`[].bloodBrainBarrier`	`String`	does drug cross blood brain barrier
`[].references`	`array<Reference>`	list of references
`[].targets`	`array<Target>`	list of targets
`[].targets[].name`	`String`	target name
`[].targets[].references`	`array<Reference>`	list of target references
`[].targets[].source`	`Object`	source database of the target
`[].targets[].targetElements`	`array<object>`	list of elements on the map associated with this target
`[].targets[].targetParticipants`	`array<object>`	list of identifiers associated with this target

[].id

String

identifier of the chemical

[].name

String

name

[].description

String

description

[].synonyms

array<string>

list of synonyms

[].brandNames

array<string>

list of brand names

[].bloodBrainBarrier

String

does drug cross blood brain barrier

[].references

array<Reference>

list of references

[].targets

array<Target>

list of targets

[].targets[].name

String

target name

[].targets[].references

array<Reference>

list of target references

[].targets[].source

Object

source database of the target

[].targets[].targetElements

array<object>

list of elements on the map associated with this target

[].targets[].targetParticipants

array<object>

list of identifiers associated with this target

1.6. Sample Response

[ {
  "name" : "Acetylsalicylic acid",
  "references" : [ {
    "link" : "https://go.drugbank.com/drugs/DB00945",
    "type" : "DRUGBANK",
    "resource" : "DB00945",
    "id" : 0,
    "annotatorClassName" : ""
  }, {
    "link" : "https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL25",
    "type" : "CHEMBL_COMPOUND",
    "resource" : "CHEMBL25",
    "id" : 0,
    "annotatorClassName" : ""
  } ],
  "description" : "Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects.  This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) [FDA label].  \n\nInterestingly, the results of various studies have demonstrated that long-term use of acetylsalicylic acid may decrease the risk of various cancers, including colorectal, esophageal, breast, lung, prostate, liver and skin cancer [A177325]. Aspirin is classified as a _non-selective cyclooxygenase (COX) inhibitor_ [A32682, A177268] and is available in many doses and forms, including chewable tablets, suppositories, extended release formulations, and others [L5968]. \n\nAcetylsalicylic acid is a very common cause of accidental poisoning in young children. It should be kept out of reach from young children, toddlers, and infants [FDA label].",
  "bloodBrainBarrier" : "N/A",
  "brandNames" : [ "Adiro", "Solprin", "Easprin", "Acetophen\n      Merck", "Aspergum", "Solprin acid", "St. Joseph Aspirin for Adults", "Aspro", "Nu-seals", "Rhodine", "Tasprin", "Rhonal", "Acenterine", "Empirin" ],
  "synonyms" : [ "O-acetylsalicylic acid", "Aspirina", "Aspirin", "o-carboxyphenyl acetate", "Acide acétylsalicylique", "2-Acetoxybenzenecarboxylic acid", "Azetylsalizylsäure", "ASA", "Acetylsalicylsäure", "Acetylsalicylate", "2-Acetoxybenzoic acid", "acide 2-(acétyloxy)benzoïque", "ácido acetilsalicílico", "Polopiryna", "Acidum acetylsalicylicum", "salicylic acid acetate", "o-acetoxybenzoic acid", "8-HOUR BAYER", "Acetosalic Acid", "ACETYLSALIC ACID", "ACETYL SALICYLATE", "Acetylsalicylic Acid", "ACETYLSALICYLIC ACID", "ACETYLSALICYLIC ACID (WHO-IP)", "ACETYLSALICYLICUM ACIDUM", "ACIDUM ACETYLSALICYLICUM", "ACIDUM ACETYLSALICYLICUM (WHO-IP)", "ALKA RAPID", "ANADIN ALL NIGHT", "ANGETTES 75", "ASPIRIN", "ASPRO CLR", "BAY1019036", "BAYER EXTRA STRENGTH ASPIRIN FOR MIGRAINE PAIN", "BENZOIC ACID, 2-(ACETYLOXY)-", "DANAMEP", "DISPRIN CV", "DISPRIN DIRECT", "DURLAZA", "Ecotrin", "ENPRIN", "Equi-Prin", "GENCARDIA", "LEVIUS", "MAX STRGH ASPRO CLR", "MEASURIN", "MICROPIRIN EC", "NSC-27223", "NSC-406186", "NU-SEALS 300", "NU-SEALS 600", "NU-SEALS 75", "NU-SEALS CARDIO 75", "PAYNOCIL", "PLATET", "PLATET 300", "POSTMI 300", "POSTMI 75", "Salicylic Acid Acetate", "VAZALORE" ],
  "id" : "Acetylsalicylic acid",
  "targets" : [ {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0004907",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "5'-AMP-activated protein kinase",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/PRKAA1",
      "type" : "HGNC_SYMBOL",
      "resource" : "PRKAA1",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/22517326/",
      "article" : null,
      "type" : "PUBMED",
      "resource" : "22517326",
      "id" : 0,
      "annotatorClassName" : ""
    }, {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/23871515/",
      "article" : null,
      "type" : "PUBMED",
      "resource" : "23871515",
      "id" : 0,
      "annotatorClassName" : ""
    }, {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/22406476/",
      "article" : null,
      "type" : "PUBMED",
      "resource" : "22406476",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "targetElements" : [ ]
  }, {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0001098",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "78 kDa glucose-regulated protein",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/HSPA5",
      "type" : "HGNC_SYMBOL",
      "resource" : "HSPA5",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/11689471/",
      "article" : null,
      "type" : "PUBMED",
      "resource" : "11689471",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "targetElements" : [ ]
  }, {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0000126",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Aldo-keto reductase family 1 member C1",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/AKR1C1",
      "type" : "HGNC_SYMBOL",
      "resource" : "AKR1C1",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/18045204/",
      "article" : null,
      "type" : "PUBMED",
      "resource" : "18045204",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "targetElements" : [ ]
  }, {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0000444",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Caspase-1",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/CASP1",
      "type" : "HGNC_SYMBOL",
      "resource" : "CASP1",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/23110215/",
      "article" : null,
      "type" : "PUBMED",
      "resource" : "23110215",
      "id" : 0,
      "annotatorClassName" : ""
    }, {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/24874482/",
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      "type" : "PUBMED",
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      "annotatorClassName" : ""
    }, {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/26980842/",
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    }, {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/30693272/",
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      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "targetElements" : [ ]
  }, {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0001162",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Caspase-3",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/CASP3",
      "type" : "HGNC_SYMBOL",
      "resource" : "CASP3",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
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      "type" : "PUBMED",
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    "targetElements" : [ ]
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      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0003380",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Cellular tumor antigen p53",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/TP53",
      "type" : "HGNC_SYMBOL",
      "resource" : "TP53",
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      "annotatorClassName" : ""
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    "references" : [ {
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      "resource" : "BE0009669",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Cyclin A",
    "targetParticipants" : [ ],
    "references" : [ {
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      "type" : "CHEMBL_TARGET",
      "resource" : "CHEMBL2094253",
      "id" : 0,
      "annotatorClassName" : ""
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    "name" : "Cyclooxygenase",
    "targetParticipants" : [ {
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    },
    "name" : "Endothelin-1 receptor",
    "targetParticipants" : [ {
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      "resource" : "EDNRA",
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    "targetElements" : [ ]
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    "name" : "Extracellular signal-regulated kinase (ERK)",
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    "references" : [ {
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    "targetElements" : [ ]
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      "resource" : "BE0001027",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "G1/S-specific cyclin-D1",
    "targetParticipants" : [ {
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    "references" : [ {
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      "annotatorClassName" : ""
    },
    "name" : "Inhibitor of nuclear factor kappa-B kinase subunit beta",
    "targetParticipants" : [ {
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    "targetElements" : [ ]
  }, {
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      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0004689",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Myc proto-oncogene protein",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/MYC",
      "type" : "HGNC_SYMBOL",
      "resource" : "MYC",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
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    } ],
    "targetElements" : [ ]
  }, {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0003469",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "NF-kappa-B inhibitor alpha",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/NFKBIA",
      "type" : "HGNC_SYMBOL",
      "resource" : "NFKBIA",
      "id" : 0,
      "annotatorClassName" : ""
    } ],
    "references" : [ {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/10553090/",
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      "type" : "PUBMED",
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    } ],
    "targetElements" : [ ]
  }, {
    "source" : {
      "link" : null,
      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0009667",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Nuclear factor kappa b beta subunit",
    "targetParticipants" : [ ],
    "references" : [ {
      "link" : "https://pubmed.ncbi.nlm.nih.gov/28718829/",
      "article" : null,
      "type" : "PUBMED",
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      "link" : "https://pubmed.ncbi.nlm.nih.gov/8052854/",
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    "targetElements" : [ ]
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      "type" : "DRUGBANK_TARGET_V4",
      "resource" : "BE0009045",
      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Proliferating cell nuclear antigen",
    "targetParticipants" : [ {
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      "type" : "HGNC_SYMBOL",
      "resource" : "PCNA",
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      "annotatorClassName" : ""
    } ],
    "references" : [ {
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    "targetElements" : [ ]
  }, {
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    "name" : "Prostaglandin G/H synthase 1",
    "targetParticipants" : [ {
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    "targetElements" : [ ]
  }, {
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      "annotatorClassName" : ""
    },
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    "targetElements" : [ ]
  }, {
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      "type" : "DRUGBANK_TARGET_V4",
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      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Ribosomal protein S6 kinase alpha-3",
    "targetParticipants" : [ {
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      "type" : "HGNC_SYMBOL",
      "resource" : "RPS6KA3",
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      "annotatorClassName" : ""
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    "targetElements" : [ ]
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      "id" : 0,
      "annotatorClassName" : ""
    },
    "name" : "Tumor necrosis factor-inducible gene 6 protein",
    "targetParticipants" : [ {
      "link" : "https://www.genenames.org/data/gene-symbol-report/#!/symbol/TNFAIP6",
      "type" : "HGNC_SYMBOL",
      "resource" : "TNFAIP6",
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} ]

2. Get suggested drug queries

Get list of suggested drug queries in the context of the project.

2.1. CURL sample

$ curl 'https://minerva-service.lcsb.uni.lu/minerva/api/projects/test_project/drugs/suggestedQueryList' -X GET \
    --cookie "MINERVA_AUTH_TOKEN=xxxxxxxx"

2.2. Path Parameters

Table 2. /minerva/api/projects/{projectId}/drugs/suggestedQueryList
Parameter	Description
`projectId`	project identifier

2.3. Response Fields

Path Type Description

Path	Type	Description
`[]`	`array<string>`	list of suggested drug queries

[]

array<string>

list of suggested drug queries

2.4. Sample Response

[ ]